STX18

Across TCGA patient cohorts, STX18 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX18-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and FoxM1. Each is linked with STX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX18-to-partner and partner-to-STX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by STX18-low versus STX18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX18→partner) and Y-score (partner→STX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.905	+3.000	.005	.037	2	1
UCEC	14-3-3_beta →	-0.144	-2.986	.013	.037	1	1
UCEC	FoxM1 →	+0.381	+3.000	.010	.037	1	1
UCEC	p62 Lck ligand →	+0.462	+3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Cyclin-B1 by STX18 expression — UCEC

Explore this box plot interactively →