STX18

Across TCGA pan-cancer cohorts, STX18 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of STX18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where STX18 RNA is repressed in tumor relative to normal tissue. In most cancer types STX18 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where STX18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.692	<.001	11	view →
LIHC	Female	II,III,IV	+0.909	<.001	9	view →
KIRP	Male	All	−0.554	<.001	7	view →
STAD	Male	II,III,IV	+0.714	<.001	6	view →
COAD	All	II,III,IV	+0.314	.001	6	view →
BLCA	All	All	+0.301	.007	6	view →
LUAD	Male	All	+0.271	<.001	6	view →
BRCA	All	All	+0.232	<.001	6	view →
THCA	Male	III,IV	−0.295	.005	4	view →
CHOL	Female	All	+2.516	<.001	3	view →
KICH	All	All	−0.606	<.001	3	view →
UCEC	All	All	+0.901	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

STX18–KIRC

Open the KIRC breakdown →