STX18

Across TCGA cell cohorts, STX18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,771 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible STX18-associated GO terms across cancer lineages are Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, Regulation of CAMKK-AMPK signaling cascade, and Positive regulation of aggrephagy. Each is linked with STX18 in more than 10 cancer types. Because this analysis shows association rather than direction, both STX18-to-partner and partner-to-STX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum grouped by STX18-low versus STX18-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STX18→partner) and Y-score (partner→STX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.063	+0.417	<.001	<.001	3	10
CNS	Regulation of CAMKK-AMPK signaling cascade →	+0.868	+0.583	<.001	<.001	3	10
BREAST	Positive regulation of aggrephagy →	+0.158	+0.626	.005	.008	2	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of CAMKK-AMPK signaling cascade →	+0.513	+0.540	.004	.001	3	10
CNS	Vesicle cytoskeletal trafficking →	+0.061	+0.468	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Autophagosome organization →	+0.069	+0.819	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,771 associations by consensus.

Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum by STX18 expression — CNS

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