STX18

Across TCGA cell cohorts, STX18 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STX18-associated genes across cancer lineages are SSMEM1, GALNTL5, and USP29. Each is linked with STX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX18-to-partner and partner-to-STX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by STX18-low versus STX18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX18→partner) and Y-score (partner→STX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LUNG_NSCLC_LUAD	GALNTL5 →	+0.076	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L13 →	+0.048	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.113	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SSMEM1 by STX18 expression — LARGE_INTESTINE

Explore this box plot interactively →