STX18-IT1

Across TCGA pan-cancer cohorts, STX18-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated STX18-IT1 data layer.

The strongest signal is observed in thymoma (THYM), where higher STX18-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated STX18-IT1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and CHOL show a favorable association.

THYM, THCA, and KIRC are the cancer types where STX18-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	II,III,IV	0.794	1.000	.001	33	view →
THCA	DFS	Tertile	IV	0.075	0.807	<.001	30	view →
KIRC	DFS	Tertile	All	0.851	0.780	.020	25	view →
CHOL	OS	Tertile	All	1.000	0.495	.009	18	view →
READ	DFS	Tertile	II,III,IV	0.436	0.762	.025	18	view →
SARC	OS	Tertile	All	0.314	0.632	<.001	18	view →
BLCA	OS	Tertile	II,III,IV	0.781	0.689	.032	15	view →
COAD	DFS	Tertile	II,III,IV	0.843	0.641	.030	15	view →
ACC	DFS	Quartile	All	0.189	0.522	.032	14	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
LIHC	DFS	Tertile	III,IV	0.111	0.346	.003	9	view →
DLBC	DFS	Tertile	II,III,IV	0.588	0.886	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

STX18-IT1–THYM (OS)

Open the THYM breakdown →