STX17

Across TCGA patient cohorts, STX17 mutation is significantly associated with the RNA expression of many other genes, with 735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX17-associated genes across cancer lineages are TPMTP3, THAP12P4, and MIR6777. Each is linked with STX17 in more than 2 cancer types. Because this analysis shows association rather than direction, both STX17-to-partner and partner-to-STX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPMTP3 grouped by STX17-low versus STX17-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX17→partner) and Y-score (partner→STX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TPMTP3 →	+0.083	+5.449	<.001	<.001	3	3
BLCA	THAP12P4 →	+0.057	+5.788	<.001	.003	3	2
BLCA	MIR6777 →	+0.497	+6.147	<.001	.002	3	2
HNSC	RNU6-508P →	+0.307	+6.357	<.001	<.001	3	2
HNSC	DHFRP5 →	+0.065	+5.936	<.001	.001	3	2
HNSC	RNA5SP239 →	+0.236	+4.655	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 735 associations by consensus.

TPMTP3 by STX17 expression — HNSC

Explore this box plot interactively →