STX16-NPEPL1

Across TCGA pan-cancer cohorts, STX16-NPEPL1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated STX16-NPEPL1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher STX16-NPEPL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STX16-NPEPL1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

KIRC, BLCA, and UCS are the cancer types where STX16-NPEPL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.454	0.716	<.001	113	view →
BLCA	DFS	Median	All	0.591	0.426	<.001	106	view →
UCS	DFS	Median	IV	0.952	0.367	.001	52	view →
PAAD	DFS	Quartile	II,III,IV	0.586	0.244	.001	46	view →
HNSC	OS	Quartile	II,III,IV	0.488	0.279	.005	44	view →
READ	OS	Median	III,IV	0.686	0.266	<.001	37	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	32	view →
LUAD	OS	Tertile	All	0.410	0.293	.003	25	view →
SKCM	OS	Tertile	IV	1.000	0.287	.006	21	view →
PRAD	DFS	Median	All	0.828	0.934	<.001	18	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	17	view →
DLBC	DFS	Median	All	0.606	0.927	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

STX16-NPEPL1–KIRC (DFS)

Open the KIRC breakdown →