STX16-NPEPL1

Across TCGA pan-cancer cohorts, STX16-NPEPL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of STX16-NPEPL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where STX16-NPEPL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STX16-NPEPL1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where STX16-NPEPL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX16-NPEPL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.977	<.001	11	view →
KIRC	Male	All	+0.220	<.001	7	view →
LIHC	All	All	+0.179	<.001	7	view →
UCEC	All	III,IV	+0.490	.014	6	view →
KICH	Female	All	−0.364	.006	4	view →
CHOL	Female	All	+0.820	.003	2	view →
READ	All	All	+0.523	.026	2	view →
THCA	All	All	−0.241	.013	2	view →
STAD	All	II,III,IV	+0.221	.046	2	view →
HNSC	All	III,IV	+0.127	.038	2	view →
LUAD	All	III,IV	−0.322	.041	1	view →
LUSC	All	All	−0.213	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

STX16-NPEPL1–COAD

Open the COAD breakdown →