STX11

Across TCGA cell cohorts, STX11 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STX11-associated genes across cancer lineages are CCDC60, PNLIPRP1, and OR2AK2. Each is linked with STX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX11-to-partner and partner-to-STX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC60 grouped by STX11-low versus STX11-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX11→partner) and Y-score (partner→STX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
OVARY	OR2AK2 →	+0.073	+4.029	<.001	.009	3	1
OVARY	ARMH2 →	+0.041	+4.228	<.001	.006	3	1
LUNG_NSCLC_LUAD	ATP6V1G3 →	+0.310	+4.093	<.001	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CCDC60 by STX11 expression — OVARY

Explore this box plot interactively →