STX10

Across TCGA cell cohorts, STX10 mutation is significantly associated with the mutation status of many other genes, with 730 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STX10-associated genes across cancer lineages are ITGB6, STARD3, and CAVIN1. Each is linked with STX10 in more than 2 cancer types. Because this analysis shows association rather than direction, both STX10-to-partner and partner-to-STX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGB6 grouped by STX10-low versus STX10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX10→partner) and Y-score (partner→STX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITGB6 →	+3.870	+4.050	.002	.002	1	3
BLOOD_Lymphoma	STARD3 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Leukemia	CAVIN1 →	+3.870	+4.050	.002	.002	1	3
BLOOD_Leukemia	TUBB1 →	+3.870	+4.050	.002	.002	1	2
BLOOD_Leukemia	TUBB4A →	+3.870	+4.050	.002	.002	1	2
BLOOD_Leukemia	SLC45A4 →	+3.115	+4.080	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

ITGB6 by STX10 expression — BLOOD_Leukemia

Explore this box plot interactively →