STT3B

Across TCGA patient cohorts, STT3B mutation is significantly associated with the RNA expression of many other genes, with 1,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STT3B-associated genes across cancer lineages are RNU7-149P, PRELID3BP5, and PLA2G12AP1. Each is linked with STT3B in more than 1 cancer types. Because this analysis shows association rather than direction, both STT3B-to-partner and partner-to-STT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-149P grouped by STT3B-low versus STT3B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STT3B→partner) and Y-score (partner→STT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU7-149P →	+0.506	+5.070	<.001	.008	3	2
SKCM	PRELID3BP5 →	+0.084	+3.043	.001	.006	3	2
UCEC	PLA2G12AP1 →	+0.353	+2.617	.004	.005	3	2
UCEC	ATP2B2-IT1 →	+0.035	+3.167	.004	.005	3	2
UCEC	PDXP →	+0.400	+2.457	.009	.001	3	2
UCEC	CORT →	+0.494	+2.447	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,417 associations by consensus.

RNU7-149P by STT3B expression — BRCA

Explore this box plot interactively →