STT3B

Across TCGA patient cohorts, STT3B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STT3B-associated genes across cancer lineages are YAP, ACC1, and Rictor_pT1135. Each is linked with STT3B in more than 2 cancer types. Because this analysis shows association rather than direction, both STT3B-to-partner and partner-to-STT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by STT3B-low versus STT3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STT3B→partner) and Y-score (partner→STT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YAP →	+0.144	+1.884	.033	.030	3	3
UCEC	ACC1 →	+0.408	+2.820	.012	.035	3	2
UCEC	Rictor_pT1135 →	-0.124	-2.000	.007	.032	3	2
UCEC	YAP_pS127 →	+0.288	+3.321	.048	.010	3	2
UCEC	Di-Ras3 →	-0.140	-3.156	.036	.018	3	2
UCEC	EGFR →	-0.227	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

YAP by STT3B expression — UCEC

Explore this box plot interactively →