STT3B

Across TCGA cell cohorts, STT3B mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STT3B-associated genes across cancer lineages are C1QC, OR10J3, and OR6C2. Each is linked with STT3B in more than 1 cancer types. Because this analysis shows association rather than direction, both STT3B-to-partner and partner-to-STT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QC grouped by STT3B-low versus STT3B-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STT3B→partner) and Y-score (partner→STT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C1QC →	+0.246	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR10J3 →	+0.033	+4.807	<.001	.006	3	1
SKIN	OR6C2 →	+0.012	+4.977	.007	.007	3	1
LARGE_INTESTINE	KPNA3 →	+0.515	+3.364	.007	.002	3	1
LARGE_INTESTINE	DDX25 →	+0.078	+2.472	<.001	.008	3	1
LARGE_INTESTINE	MOB1A →	+0.396	+3.451	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

C1QC by STT3B expression — BLOOD_Myeloma

Explore this box plot interactively →