STT3A

Across TCGA patient cohorts, STT3A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STT3A-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ACC1. Each is linked with STT3A in more than 1 cancer types. Because this analysis shows association rather than direction, both STT3A-to-partner and partner-to-STT3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by STT3A-low versus STT3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STT3A→partner) and Y-score (partner→STT3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-3.432	.005	.005	3	1
UCEC	eIF4E →	+0.211	+2.807	.005	<.001	3	1
UCEC	ACC1 →	+0.260	+1.584	.046	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.115	.003	.017	3	1
UCEC	MEK1 →	+0.324	+1.807	.013	.025	3	1
UCEC	MSH2 →	-0.182	-1.848	.028	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by STT3A expression — UCEC

Explore this box plot interactively →