STT3A

Across TCGA pan-cancer cohorts, STT3A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of STT3A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STT3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STT3A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where STT3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STT3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.988	<.001	12	view →
KIRC	Female	IV	+0.781	<.001	12	view →
BLCA	All	III,IV	+0.738	<.001	11	view →
LIHC	Female	II,III,IV	+1.420	<.001	9	view →
THCA	All	IV	−1.087	<.001	9	view →
LUAD	Male	II,III,IV	+0.988	<.001	9	view →
COAD	Male	II,III,IV	+0.804	<.001	9	view →
STAD	Male	II,III,IV	+1.037	<.001	8	view →
LUSC	All	II,III,IV	+0.874	<.001	8	view →
KIRP	All	IV	+0.875	.010	6	view →
BRCA	All	All	+0.432	<.001	6	view →
CHOL	Male	All	+1.820	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

STT3A–HNSC

Open the HNSC breakdown →