STRADA

Across TCGA patient cohorts, STRADA mutation is significantly associated with the RNA expression of many other genes, with 1,478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRADA-associated genes across cancer lineages are RFPL4AP3, OR8G7P, and RPL17-C18orf32. Each is linked with STRADA in more than 1 cancer types. Because this analysis shows association rather than direction, both STRADA-to-partner and partner-to-STRADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL4AP3 grouped by STRADA-low versus STRADA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRADA→partner) and Y-score (partner→STRADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFPL4AP3 →	+0.154	+5.736	<.001	.003	3	2
HNSC	OR8G7P →	+0.098	+5.822	<.001	.003	3	2
UCEC	RPL17-C18orf32 →	+0.055	+2.186	<.001	<.001	3	2
CESC	LINC01446 →	+0.391	+4.269	<.001	.003	3	2
BRCA	TSPY18P →	+0.057	+7.057	<.001	.009	3	2
BRCA	FLYWCH1P1 →	+0.021	+3.812	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,478 associations by consensus.

RFPL4AP3 by STRADA expression — HNSC

Explore this box plot interactively →