STRA6

Across TCGA cell cohorts, STRA6 mutation is significantly associated with the RNA expression of many other genes, with 648 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRA6-associated genes across cancer lineages are PRM3, C22orf31, and XPNPEP2. Each is linked with STRA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRA6-to-partner and partner-to-STRA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM3 grouped by STRA6-low versus STRA6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRA6→partner) and Y-score (partner→STRA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	C22orf31 →	+0.029	+4.050	.005	.004	3	1
LUNG_NSCLC_LUAD	XPNPEP2 →	+0.153	+4.485	<.001	.001	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.057	+4.157	<.001	.003	3	1
LUNG_NSCLC_LUAD	RNASE3 →	+0.072	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.011	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

PRM3 by STRA6 expression — CNS

Explore this box plot interactively →