STPG2

Across TCGA patient cohorts, STPG2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STPG2-associated genes across cancer lineages are ASNS, Gab2, and p27_pT198. Each is linked with STPG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STPG2-to-partner and partner-to-STPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by STPG2-low versus STPG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STPG2→partner) and Y-score (partner→STPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.286	+1.584	.022	.034	3	3
UCEC	Gab2 →	+0.310	+2.321	.012	.034	3	2
UCEC	p27_pT198 →	+0.093	+2.700	.012	.006	3	2
UCEC	PAI-1 →	+0.286	+1.440	.016	.024	3	2
UCEC	STAT3_pY705 →	-0.433	-2.070	<.001	.001	3	2
UCEC	TFRC →	+0.447	+1.874	.015	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ASNS by STPG2 expression — UCEC

Explore this box plot interactively →