STPG1

Across TCGA cell cohorts, STPG1 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STPG1-associated genes across cancer lineages are Pevonedistat, 150412, and GSK2276186C. Each is linked with STPG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STPG1-to-partner and partner-to-STPG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pevonedistat grouped by STPG1-low versus STPG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STPG1→partner) and Y-score (partner→STPG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Pevonedistat →	+0.728	+2.649	.034	.046	3	1
LARGE_INTESTINE	150412 →	+0.321	+3.000	.045	.017	3	1
LARGE_INTESTINE	GSK2276186C →	+0.455	+2.871	.038	.021	2	1
LARGE_INTESTINE	GSK1070916 →	+0.666	+2.655	.025	.044	2	1
LARGE_INTESTINE	GSK429286A →	+0.436	+2.874	.002	.021	2	1
LARGE_INTESTINE	Cabozantinib →	+0.403	+2.874	.045	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Pevonedistat by STPG1 expression — LARGE_INTESTINE

Explore this box plot interactively →