STOX2

Across TCGA patient cohorts, STOX2 mutation is significantly associated with the RNA expression of many other genes, with 3,047 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STOX2-associated genes across cancer lineages are RCHY1, SLBP, and PCLAF. Each is linked with STOX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STOX2-to-partner and partner-to-STOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCHY1 grouped by STOX2-low versus STOX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOX2→partner) and Y-score (partner→STOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCHY1 →	+0.404	+2.362	<.001	.003	3	3
UCEC	SLBP →	+0.364	+1.489	.003	.003	3	3
UCEC	PCLAF →	+0.439	+1.593	.008	.002	3	3
CESC	ZNF33CP →	+0.018	+4.539	.003	.008	3	3
SKCM	ATP2A1 →	+0.342	+3.522	.002	.002	3	3
UCEC	C1orf174 →	+0.324	+1.470	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,047 associations by consensus.

RCHY1 by STOX2 expression — COAD

Explore this box plot interactively →