STON1-GTF2A1L

Across TCGA pan-cancer cohorts, STON1-GTF2A1L RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated STON1-GTF2A1L data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher STON1-GTF2A1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STON1-GTF2A1L expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

ACC, HNSC, and KIRC are the cancer types where STON1-GTF2A1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	III,IV	0.073	0.529	<.001	99	view →
HNSC	DFS	Median	All	0.698	0.554	<.001	70	view →
KIRC	DFS	Median	IV	0.620	0.373	.001	68	view →
BRCA	DFS	Median	All	0.445	0.581	<.001	45	view →
READ	DFS	Median	All	0.264	0.757	.003	34	view →
UCEC	DFS	Tertile	All	0.532	0.683	<.001	24	view →
CHOL	DFS	Median	II,III,IV	0.834	0.124	.003	18	view →
COAD	OS	Median	All	0.821	0.911	.008	12	view →
GBM	DFS	Median	All	0.314	0.181	.006	12	view →
STAD	OS	Quartile	All	0.278	0.535	.018	12	view →
LIHC	DFS	Quartile	II,III,IV	0.526	0.265	.021	12	view →
PAAD	OS	Quartile	II,III,IV	0.662	0.444	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

STON1-GTF2A1L–ACC (DFS)

Open the ACC breakdown →