STK32A

Across TCGA patient cohorts, STK32A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK32A-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Ku80. Each is linked with STK32A in more than 1 cancer types. Because this analysis shows association rather than direction, both STK32A-to-partner and partner-to-STK32A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by STK32A-low versus STK32A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK32A→partner) and Y-score (partner→STK32A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.087	-2.295	.026	.033	3	1
UCEC	JNK2 →	+0.268	+3.169	<.001	<.001	3	1
UCEC	Ku80 →	+0.250	+2.335	.006	.018	3	1
UCEC	MEK1 →	+0.436	+3.807	.002	<.001	3	1
UCEC	MSH2 →	-0.297	-2.558	.001	.010	3	1
UCEC	p27_pT198 →	+0.083	+2.459	.048	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by STK32A expression — UCEC

Explore this box plot interactively →