STK3

Across TCGA patient cohorts, STK3 mutation is significantly associated with the RNA expression of many other genes, with 2,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK3-associated genes across cancer lineages are UBTFL11, C7orf66, and DEFB135. Each is linked with STK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both STK3-to-partner and partner-to-STK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBTFL11 grouped by STK3-low versus STK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK3→partner) and Y-score (partner→STK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBTFL11 →	+0.053	+1.397	.002	.004	3	3
BLCA	C7orf66 →	+0.192	+3.398	<.001	.003	3	2
BLCA	DEFB135 →	+0.119	+4.122	<.001	.008	3	2
BLCA	MIR760 →	+0.658	+3.326	<.001	.004	3	2
UCEC	RNA5SP86 →	+0.327	+2.026	<.001	.004	3	2
UCEC	MIR8082 →	+0.269	+1.806	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,490 associations by consensus.

UBTFL11 by STK3 expression — UCEC

Explore this box plot interactively →