STK3

Across TCGA pan-cancer cohorts, STK3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated STK3 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher STK3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LAML show a favorable association.

KIRP, UVM, and LGG are the cancer types where STK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.744	0.935	<.001	57	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	56	view →
LGG	OS	Median	All	0.342	0.569	<.001	53	view →
PAAD	OS	Tertile	All	0.315	0.671	<.001	53	view →
HNSC	OS	Quartile	All	0.235	0.525	<.001	44	view →
LUSC	DFS	Tertile	III,IV	0.180	0.578	.001	38	view →
LIHC	OS	Median	All	0.395	0.623	.001	36	view →
OV	DFS	Tertile	All	0.476	0.566	.009	28	view →
KIRC	OS	Quartile	All	0.725	0.518	.003	28	view →
BRCA	OS	Tertile	All	0.889	0.940	.004	24	view →
LAML	DFS	Tertile	All	0.585	0.278	.015	24	view →
CESC	DFS	Median	All	0.777	0.863	.006	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

STK3–KIRP (DFS)

Open the KIRP breakdown →