STK3

Across TCGA patient cohorts, STK3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK3-associated genes across cancer lineages are mTOR_pS2448, ASNS, and ATM. Each is linked with STK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK3-to-partner and partner-to-STK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by STK3-low versus STK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK3→partner) and Y-score (partner→STK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.116	-1.794	.022	.024	3	2
UCEC	ASNS →	+0.302	+2.222	.014	.009	3	2
UCEC	ATM →	-0.511	-2.794	<.001	.002	3	2
UCEC	Cyclin-E2 →	+0.129	+1.514	.024	.015	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.700	.003	.005	3	1
UCEC	eIF4E →	+0.155	+2.598	.030	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by STK3 expression — UCEC

Explore this box plot interactively →