STK25

Across TCGA patient cohorts, STK25 mutation is significantly associated with the RNA expression of many other genes, with 1,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK25-associated genes across cancer lineages are GBP5, VPS37A, and CXCL13. Each is linked with STK25 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK25-to-partner and partner-to-STK25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBP5 grouped by STK25-low versus STK25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK25→partner) and Y-score (partner→STK25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GBP5 →	+0.975	+2.233	.004	.006	3	2
UCEC	VPS37A →	+0.671	+3.332	<.001	.005	3	2
UCEC	CXCL13 →	+1.895	+4.000	<.001	<.001	3	2
UCEC	ABHD3 →	+0.844	+4.010	<.001	<.001	3	2
UCEC	SFXN1 →	+0.566	+3.480	<.001	.002	3	2
UCEC	MAP2K1 →	+0.556	+2.243	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,156 associations by consensus.

GBP5 by STK25 expression — UCEC

Explore this box plot interactively →