STK25

Across TCGA pan-cancer cohorts, STK25 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of STK25’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where STK25 RNA is repressed in tumor relative to normal tissue. In most cancer types STK25 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and COAD are the cancer types where STK25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STK25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.830	<.001	11	view →
HNSC	All	II,III,IV	+0.428	<.001	11	view →
COAD	Female	All	+0.742	<.001	10	view →
KIRC	Female	III,IV	+0.533	<.001	10	view →
LIHC	Female	II,III,IV	+1.060	<.001	9	view →
KICH	Male	All	−1.126	<.001	8	view →
STAD	Male	II,III,IV	+0.976	<.001	6	view →
UCEC	All	II,III,IV	+0.371	.016	6	view →
LUAD	Male	All	+0.348	.001	6	view →
CHOL	Female	All	+2.166	<.001	5	view →
LUSC	Male	All	+0.349	<.001	5	view →
READ	All	All	+0.523	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

STK25–THCA

Open the THCA breakdown →