STK17A

Across TCGA patient cohorts, STK17A mutation is significantly associated with the RNA expression of many other genes, with 1,192 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK17A-associated genes across cancer lineages are MIR6870, RNA5SP164, and GTF3C6P1. Each is linked with STK17A in more than 1 cancer types. Because this analysis shows association rather than direction, both STK17A-to-partner and partner-to-STK17A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6870 grouped by STK17A-low versus STK17A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK17A→partner) and Y-score (partner→STK17A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6870 →	+0.347	+2.174	<.001	.008	3	2
UCEC	RNA5SP164 →	+0.090	+3.890	<.001	.007	3	2
COAD	GTF3C6P1 →	+0.270	+5.017	<.001	.009	3	2
COAD	MTCO3P46 →	+0.611	+5.602	<.001	.004	3	2
UCEC	COX15 →	+0.399	+2.512	.005	.009	3	1
UCEC	MTA2 →	+0.371	+2.064	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,192 associations by consensus.

MIR6870 by STK17A expression — UCEC

Explore this box plot interactively →