STK17A

Across TCGA pan-cancer cohorts, STK17A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated STK17A data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher STK17A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK17A expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

KIRP, SKCM, and HNSC are the cancer types where STK17A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.759	0.948	<.001	74	view →
SKCM	OS	Median	All	0.418	0.254	<.001	47	view →
HNSC	OS	Tertile	All	0.718	0.805	.010	45	view →
LGG	OS	Median	All	0.747	0.873	<.001	43	view →
MESO	OS	Quartile	All	0.280	0.612	<.001	43	view →
LIHC	OS	Tertile	All	0.385	0.632	<.001	42	view →
ESCA	DFS	Quartile	III,IV	0.585	0.293	.001	35	view →
UVM	DFS	Tertile	III,IV	0.272	0.854	.002	22	view →
STAD	DFS	Tertile	All	0.482	0.619	.016	20	view →
UCS	DFS	Tertile	IV	0.938	0.361	.024	12	view →
KIRC	DFS	Quartile	IV	0.299	0.569	.024	10	view →
UCEC	OS	Tertile	II,III,IV	0.762	0.593	.036	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

STK17A–KIRP (DFS)

Open the KIRP breakdown →