STK11IP

Across TCGA patient cohorts, STK11IP mutation is significantly associated with the RNA expression of many other genes, with 4,973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK11IP-associated genes across cancer lineages are PEBP1P1, CHEK1, and CENPU. Each is linked with STK11IP in more than 2 cancer types. Because this analysis shows association rather than direction, both STK11IP-to-partner and partner-to-STK11IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEBP1P1 grouped by STK11IP-low versus STK11IP-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11IP→partner) and Y-score (partner→STK11IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PEBP1P1 →	+0.093	+4.276	<.001	.008	3	3
UCEC	CHEK1 →	+0.523	+2.269	<.001	<.001	3	3
UCEC	CENPU →	+0.625	+1.890	<.001	<.001	3	3
UCEC	ZUP1 →	+0.338	+1.546	.003	.008	3	3
SKCM	SUPV3L1 →	+0.437	+3.699	.001	<.001	3	3
UCEC	BUB1B →	+0.610	+2.671	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,973 associations by consensus.

PEBP1P1 by STK11IP expression — CESC

Explore this box plot interactively →