STK11IP

Across TCGA patient cohorts, STK11IP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK11IP-associated genes across cancer lineages are Cyclin-B1, ASNS, and MSH2. Each is linked with STK11IP in more than 2 cancer types. Because this analysis shows association rather than direction, both STK11IP-to-partner and partner-to-STK11IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by STK11IP-low versus STK11IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11IP→partner) and Y-score (partner→STK11IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.673	+2.523	<.001	<.001	3	3
UCEC	ASNS →	+0.293	+1.584	.017	.034	3	3
LUAD	MSH2 →	+0.395	+2.824	.013	.036	3	2
UCEC	ACC1 →	+0.362	+1.514	.003	.015	3	2
SKCM	PREX1 →	-0.298	-2.321	.049	.033	3	2
SKCM	Collagen-VI →	-0.325	-3.169	.041	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Cyclin-B1 by STK11IP expression — UCEC

Explore this box plot interactively →