STK11

Across TCGA pan-cancer cohorts, STK11 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STK11 data layer compared with 26 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher STK11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK11 expression acts as an unfavorable survival marker.

UCEC, LUAD, and PDAC are the cancer types where STK11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.555	1.000	.022	16	view →
LUAD	DFS	Median	III,IV	0.350	0.686	.023	6	view →
PDAC	OS	Median	III,IV	0.614	1.000	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STK11–UCEC (DFS)

Open the UCEC breakdown →