STK11

Across TCGA pan-cancer cohorts, STK11 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of STK11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where STK11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STK11 is over-expressed in tumor.

COAD, LIHC, and STAD are the cancer types where STK11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STK11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.590	<.001	9	view →
LIHC	Female	II,III,IV	+1.008	<.001	8	view →
STAD	Male	II,III,IV	+0.818	<.001	6	view →
BLCA	All	All	+0.305	.012	5	view →
HNSC	All	All	+0.372	.001	4	view →
CHOL	Male	All	+1.475	<.001	3	view →
LUSC	All	All	+0.331	<.001	3	view →
KIRC	Female	All	+0.310	.001	3	view →
READ	Female	All	+0.586	.036	2	view →
PAAD	Male	All	+0.395	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

STK11–COAD

Open the COAD breakdown →