STK11

Across TCGA patient cohorts, STK11 protein abundance is significantly associated with the RNA expression of many other genes, with 8,639 significant associations in total. GBM shows the largest number of these associations.

The most reproducible STK11-associated genes across cancer lineages are KLHDC1, AURKA, and C21orf62-AS1. Each is linked with STK11 in more than 3 cancer types. Because this analysis shows association rather than direction, both STK11-to-partner and partner-to-STK11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STK11 versus KLHDC1 in BRCA, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11→partner) and Y-score (partner→STK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLHDC1 →	+0.694	+0.272	.002	<.001	3	4
UCEC	AURKA →	-1.186	-0.221	<.001	.003	3	4
LUAD	C21orf62-AS1 →	+0.347	+0.256	<.001	.001	3	3
UCEC	FOXM1 →	-0.861	-0.195	<.001	<.001	3	3
LUAD	ZNF493 →	+0.825	+0.318	<.001	<.001	3	3
BRCA	ZNF737 →	+0.744	+0.210	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,639 associations by consensus.

STK11 vs KLHDC1 — BRCA

Explore this scatter interactively →