STK11

Across TCGA patient cohorts, STK11 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible STK11-associated genes across cancer lineages are G6PD, Heregulin, and INPP4B. Each is linked with STK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK11-to-partner and partner-to-STK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by STK11-low versus STK11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11→partner) and Y-score (partner→STK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	G6PD →	+0.341	+2.222	.015	.009	3	2
LUAD	Heregulin →	+0.085	+2.186	.048	.032	3	2
LUAD	INPP4B →	-0.325	-3.459	.013	.004	3	2
LUAD	EGFR →	-0.226	-2.321	.003	<.001	3	1
LUAD	FASN →	+0.498	+2.000	<.001	<.001	3	1
LUAD	FoxM1 →	+0.166	+1.222	.037	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

G6PD by STK11 expression — LUAD

Explore this box plot interactively →