STK11

Across TCGA cell cohorts, STK11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,499 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible STK11-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Energy coupled proton transmembrane transport, against electrochemical gradient, and Electron transport coupled proton transport. Each is linked with STK11 in more than 17 cancer types. Because this analysis shows association rather than direction, both STK11-to-partner and partner-to-STK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by STK11-low versus STK11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11→partner) and Y-score (partner→STK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.205	+1.106	<.001	<.001	3	18
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.107	+0.878	<.001	<.001	3	16
BONE	Electron transport coupled proton transport →	+0.107	+0.878	<.001	<.001	3	16
BONE	Negative regulation of transcription elongation by RNA polymerase II →	+0.147	+0.926	<.001	<.001	3	14
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.154	+0.895	<.001	<.001	3	14
BONE	Negative regulation of protein localization to chromatin →	+0.180	+0.791	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,499 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by STK11 expression — BONE

Explore this box plot interactively →