STK11

Across TCGA cell cohorts, STK11 mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STK11-associated genes across cancer lineages are PLCL1, NAXE, and HSPA12A. Each is linked with STK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK11-to-partner and partner-to-STK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCL1 grouped by STK11-low versus STK11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK11→partner) and Y-score (partner→STK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLCL1 →	+0.116	+2.000	.002	.003	3	2
LUNG_NSCLC_LUAD	NAXE →	+0.654	+2.206	<.001	<.001	3	2
LUNG_NSCLC_LUAD	HSPA12A →	+0.742	+2.699	<.001	<.001	3	2
LUNG_NSCLC_LUAD	TMEM253 →	+0.332	+2.115	.004	.005	3	2
LUNG_SCLC	IFNA1 →	+0.096	+5.029	.002	.006	3	1
LUNG_NSCLC_LUAD	SLC8A3 →	+0.160	+2.122	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

PLCL1 by STK11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →