STK10

Across TCGA pan-cancer cohorts, STK10 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated STK10 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher STK10 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, UCS, and HNSC are the cancer types where STK10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.082	0.548	<.001	42	view →
UCS	OS	Median	All	0.102	0.688	<.001	36	view →
HNSC	OS	Median	II,III,IV	0.329	0.653	.010	24	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
STAD	OS	Median	III,IV	0.164	0.633	.002	18	view →
LUAD	OS	Median	III,IV	0.153	0.663	.004	18	view →
ESCA	OS	Median	III,IV	0.130	0.574	.011	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	III,IV	0.906	0.533	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

STK10–CESC (DFS)

Open the CESC breakdown →