STK10

Across TCGA pan-cancer cohorts, STK10 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of STK10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STK10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STK10 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where STK10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STK10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.506	<.001	12	view →
KIRC	Female	All	+1.376	<.001	12	view →
STAD	Male	II,III,IV	+1.219	<.001	8	view →
LIHC	Female	II,III,IV	+1.065	<.001	8	view →
LUSC	Female	All	−1.295	<.001	6	view →
ESCA	All	All	+1.018	.001	5	view →
LUAD	Female	All	−0.592	<.001	5	view →
KIRP	All	All	+0.511	.001	5	view →
CHOL	All	All	+1.488	<.001	3	view →
KICH	All	All	−0.653	.001	3	view →
UCEC	All	All	−0.475	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

STK10–HNSC

Open the HNSC breakdown →