STK10

Across TCGA pan-cancer cohorts, STK10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STK10 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher STK10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK10 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

GBM, CCRCC, and HNSC are the cancer types where STK10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.646	0.933	<.001	19	view →
CCRCC	OS	Tertile	All	0.573	1.000	.008	5	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	2	view →
PDAC	OS	Tertile	III,IV	0.621	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STK10–GBM (DFS)

Open the GBM breakdown →