STK10

Across TCGA patient cohorts, STK10 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK10-associated genes across cancer lineages are eEF2, Lck, and A-Raf_pS299. Each is linked with STK10 in more than 2 cancer types. Because this analysis shows association rather than direction, both STK10-to-partner and partner-to-STK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by STK10-low versus STK10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK10→partner) and Y-score (partner→STK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.386	+1.514	.001	.015	3	2
COAD	Lck →	+0.311	+2.484	.019	.010	3	2
UCEC	A-Raf_pS299 →	-0.166	-2.502	<.001	.001	3	2
UCEC	ERK2 →	+0.199	+2.000	.002	.029	3	2
UCEC	GAPDH →	+0.549	+3.807	.002	<.001	3	2
UCEC	mTOR_pS2448 →	-0.134	-2.302	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eEF2 by STK10 expression — UCEC

Explore this box plot interactively →