STK10

Across TCGA cell cohorts, STK10 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STK10-associated genes across cancer lineages are GRIFIN, OR2T35, and KRTAP10-6. Each is linked with STK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK10-to-partner and partner-to-STK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by STK10-low versus STK10-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK10→partner) and Y-score (partner→STK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GRIFIN →	+0.135	+5.029	<.001	.006	3	1
BREAST	OR2T35 →	+0.023	+5.169	<.001	.005	3	1
BREAST	KRTAP10-6 →	+0.012	+5.169	<.001	.005	3	1
BREAST	OR11G2 →	+0.013	+5.169	<.001	.005	3	1
BREAST	KRTAP10-10 →	+0.022	+5.169	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	MRGPRD →	+0.130	+3.584	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

GRIFIN by STK10 expression — LUNG_SCLC

Explore this box plot interactively →