STK10

Across TCGA cell cohorts, STK10 mutation is significantly associated with the mutation status of many other genes, with 5,198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STK10-associated genes across cancer lineages are CACNA1E, PLXNA4, and BICRA. Each is linked with STK10 in more than 5 cancer types. Because this analysis shows association rather than direction, both STK10-to-partner and partner-to-STK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1E grouped by STK10-low versus STK10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK10→partner) and Y-score (partner→STK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CACNA1E →	+1.643	+3.145	<.001	<.001	1	6
OVARY	PLXNA4 →	+3.310	+4.688	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	BICRA →	+4.193	+4.193	.002	.002	1	5
BLOOD_Leukemia	PTPRD →	+2.078	+2.686	.005	.005	1	5
BLOOD_Leukemia	TBC1D9B →	+2.341	+2.638	.009	.009	1	5
BREAST	C6 →	+4.297	+4.857	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,198 associations by consensus.

CACNA1E by STK10 expression — LARGE_INTESTINE

Explore this box plot interactively →