STIM2

Across TCGA cell cohorts, STIM2 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STIM2-associated genes across cancer lineages are HTN3, SLC22A24, and IFNA14. Each is linked with STIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STIM2-to-partner and partner-to-STIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN3 grouped by STIM2-low versus STIM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM2→partner) and Y-score (partner→STIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTN3 →	+0.077	+2.462	<.001	.004	3	3
BREAST	SLC22A24 →	+0.007	+5.312	<.001	<.001	3	2
BREAST	IFNA14 →	+0.027	+4.781	<.001	.003	3	2
BONE	VN1R3 →	+0.046	+5.169	<.001	.004	3	1
OESOPHAGUS	OR5B12 →	+0.016	+4.392	<.001	.003	3	1
OESOPHAGUS	LCE1B →	+0.055	+4.017	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

HTN3 by STIM2 expression — LARGE_INTESTINE

Explore this box plot interactively →