STIM2-AS1

Across TCGA pan-cancer cohorts, STIM2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated STIM2-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher STIM2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated STIM2-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUAD show a favorable association.

KICH, LAML, and CESC are the cancer types where STIM2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.624	1.000	.005	51	view →
LAML	DFS	Median	All	0.309	0.629	<.001	42	view →
CESC	DFS	Quartile	III,IV	0.899	0.517	.007	26	view →
LUAD	DFS	Quartile	All	0.827	0.668	.011	24	view →
HNSC	OS	Quartile	All	0.551	0.725	.006	22	view →
LGG	DFS	Tertile	All	0.644	0.815	<.001	22	view →
SKCM	DFS	Tertile	IV	0.077	0.810	.013	21	view →
PAAD	OS	Quartile	All	0.558	0.244	.024	13	view →
BLCA	DFS	Median	III,IV	0.205	0.373	.009	13	view →
UCS	DFS	Tertile	IV	0.978	0.419	.036	12	view →
ESCA	OS	Median	All	0.449	1.000	.011	11	view →
THCA	OS	Median	All	0.963	1.000	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

STIM2-AS1–KICH (OS)

Open the KICH breakdown →