STIM1

Across TCGA patient cohorts, STIM1 mutation is significantly associated with the RNA expression of many other genes, with 1,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIM1-associated genes across cancer lineages are TAF9, RNU6-374P, and LIN7C. Each is linked with STIM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STIM1-to-partner and partner-to-STIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by STIM1-low versus STIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM1→partner) and Y-score (partner→STIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.593	+2.662	<.001	<.001	3	3
BRCA	RNU6-374P →	+0.214	+9.057	<.001	.003	3	2
UCEC	LIN7C →	+0.564	+2.850	.001	.001	3	2
UCEC	TMEM263 →	+0.501	+2.230	.006	.006	3	2
UCEC	CCDC3 →	-0.782	-2.662	.003	<.001	3	2
UCEC	SAR1B →	+0.490	+2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,496 associations by consensus.

TAF9 by STIM1 expression — UCEC

Explore this box plot interactively →