STIM1

Across TCGA pan-cancer cohorts, STIM1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of STIM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where STIM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STIM1 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

KIRP, KICH, and COAD are the cancer types where STIM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STIM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.000	<.001	11	view →
KICH	Female	II,III,IV	+1.864	<.001	10	view →
COAD	Female	II,III,IV	−0.781	<.001	10	view →
LIHC	Female	II,III,IV	+1.207	<.001	9	view →
KIRC	Male	IV	+0.728	<.001	9	view →
BRCA	All	III,IV	−0.532	<.001	6	view →
READ	All	All	−0.801	<.001	5	view →
BLCA	All	All	−0.541	.003	5	view →
UCEC	All	All	−0.799	<.001	4	view →
CHOL	Female	All	+1.420	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

STIM1–KIRP

Open the KIRP breakdown →