STIM1

Across TCGA patient cohorts, STIM1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIM1-associated genes across cancer lineages are ACC1, Rad50, and eIF4E. Each is linked with STIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STIM1-to-partner and partner-to-STIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by STIM1-low versus STIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM1→partner) and Y-score (partner→STIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.369	+2.000	.009	.010	3	2
UCEC	Rad50 →	-0.208	-2.459	.029	.019	3	2
UCEC	eIF4E →	+0.193	+2.000	.019	.010	2	2
UCEC	eIF4G →	+0.308	+3.459	.011	.005	3	1
UCEC	FASN →	+0.321	+2.000	.038	.010	3	1
UCEC	JNK2 →	+0.247	+3.026	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ACC1 by STIM1 expression — UCEC

Explore this box plot interactively →