STIL

Across TCGA patient cohorts, STIL mutation is significantly associated with the RNA expression of many other genes, with 4,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIL-associated genes across cancer lineages are MIR4774, RPL32P32, and TMEM269. Each is linked with STIL in more than 2 cancer types. Because this analysis shows association rather than direction, both STIL-to-partner and partner-to-STIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by STIL-low versus STIL-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIL→partner) and Y-score (partner→STIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	3
BLCA	RPL32P32 →	+0.510	+3.501	<.001	.002	3	3
UCEC	TMEM269 →	+0.146	+1.817	<.001	.003	3	3
UCEC	SH3GL1 →	+0.479	+2.042	<.001	<.001	3	3
LUSC	PACS2 →	+0.569	+3.333	.002	.005	3	3
READ	ANKRD33B-AS1 →	+0.187	+6.681	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,351 associations by consensus.

MIR4774 by STIL expression — READ

Explore this box plot interactively →