STIL

Across TCGA pan-cancer cohorts, STIL RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of STIL’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STIL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STIL is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where STIL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STIL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.311	<.001	11	view →
HNSC	Male	All	+1.403	<.001	11	view →
COAD	Female	II,III,IV	+1.325	<.001	11	view →
KIRP	All	II,III,IV	+1.181	<.001	11	view →
KIRC	Male	All	+0.524	<.001	11	view →
LUAD	Male	III,IV	+2.255	<.001	9	view →
LIHC	Female	II,III,IV	+1.148	<.001	9	view →
LUSC	Female	All	+2.715	<.001	8	view →
STAD	Female	All	+2.401	<.001	8	view →
UCEC	All	III,IV	+2.662	<.001	6	view →
BRCA	All	II,III,IV	+1.624	<.001	6	view →
CHOL	Male	All	+2.886	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

STIL–BLCA

Open the BLCA breakdown →